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The disease seems to spread mainly after an infected person breathes, coughs, sneezes, talks or sings. It may be possible that a person can get COVID through indirect contact by touching a contaminated surface or object , and then touching their own mouth, nose, or possibly their eyes, [39] though this is not thought to be the main way the virus spreads, and it has not been conclusively demonstrated.

Social distancing and the wearing of cloth face masks, surgical masks, respirators, or other face coverings are controls for droplet transmission.

Transmission may be decreased indoors with well maintained heating and ventilation systems to maintain good air circulation and increase the use of outdoor air.

It was first isolated from three people with pneumonia connected to the cluster of acute respiratory illness cases in Wuhan.

Outside the human body, the virus is destroyed by household soap, which bursts its protective bubble. Genetic analysis has revealed that the coronavirus genetically clusters with the genus Betacoronavirus , in subgenus Sarbecovirus lineage B together with two bat-derived strains.

COVID can affect the upper respiratory tract sinuses, nose, and throat and the lower respiratory tract windpipe and lungs. While virus has been detected in cerebrospinal fluid of autopsies, the exact mechanism by which it invades the CNS remains unclear and may first involve invasion of peripheral nerves given the low levels of ACE2 in the brain.

The virus also affects gastrointestinal organs as ACE2 is abundantly expressed in the glandular cells of gastric , duodenal and rectal epithelium [61] as well as endothelial cells and enterocytes of the small intestine.

The virus can cause acute myocardial injury and chronic damage to the cardiovascular system. Infection appears to set off a chain of vasoconstrictive responses within the body, constriction of blood vessels within the pulmonary circulation has also been posited as a mechanism in which oxygenation decreases alongside the presentation of viral pneumonia.

Another common cause of death is complications related to the kidneys. Systemic inflammation results in vasodilation , allowing inflammatory lymphocytic and monocytic infiltration of the lung and the heart.

The WHO has published several testing protocols for the disease. Diagnostic guidelines released by Zhongnan Hospital of Wuhan University suggested methods for detecting infections based upon clinical features and epidemiological risk.

These involved identifying people who had at least two of the following symptoms in addition to a history of travel to Wuhan or contact with other infected people: fever, imaging features of pneumonia, normal or reduced white blood cell count, or reduced lymphocyte count.

This technique has the potential of being quicker than a swab and involving less risk to health care workers collection at home or in the car.

Along with laboratory testing, chest CT scans may be helpful to diagnose COVID in individuals with a high clinical suspicion of infection but are not recommended for routine screening.

The main pathological findings at autopsy are: [70]. Preventive measures to reduce the chances of infection include staying at home, wearing a mask in public, avoiding crowded places, keeping distance from others, washing hands with soap and water often and for at least 20 seconds, practising good respiratory hygiene, and avoiding touching the eyes, nose, or mouth with unwashed hands.

For health care professionals who may come into contact with COVID positive bodily fluids, using personal protective coverings on exposed body parts improves protection from the virus.

Masks are also strongly recommended for those who may have been infected and those taking care of someone who may have the disease. Social distancing strategies aim to reduce contact of infected persons with large groups by closing schools and workplaces, restricting travel, and cancelling large public gatherings.

When not wearing a mask, the CDC, WHO, and NHS recommends covering the mouth and nose with a tissue when coughing or sneezing and recommends using the inside of the elbow if no tissue is available.

In these formulations, the antimicrobial activity arises from ethanol or isopropanol. Hydrogen peroxide is used to help eliminate bacterial spores in the alcohol; it is "not an active substance for hand antisepsis ".

Glycerol is added as a humectant. Sanitizing of frequently touched surfaces is also recommended or required by regulation for businesses and public facilities; the United States Environmental Protection Agency maintains a list of products expected to be effective.

People are managed with supportive care , which may include fluid therapy , oxygen support , and supporting other affected vital organs.

The disease may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold.

Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover.

Among those who have died, the time from symptom onset to death has ranged from two to eight weeks. However, people transferred to an ICU had a median time of ten days between hospitalisation and death.

Mortality rates are highly correlated to age. In those younger than 50 years the risk of death is less than 0. Four of those children 0.

Most of those who die of COVID have pre-existing underlying conditions , including hypertension , diabetes mellitus , and cardiovascular disease.

Most critical respiratory comorbidities according to the CDC , are: moderate or severe asthma , pre-existing COPD , pulmonary fibrosis , cystic fibrosis.

Complications may include pneumonia , acute respiratory distress syndrome ARDS , multi-organ failure , septic shock , and death. Cardiovascular complications may include heart failure, arrhythmias , heart inflammation , and blood clots.

Concerns have been raised about long-term sequelae of the disease, while patients with a severe form of the acute disease may also suffer from post-intensive care syndrome following recovery.

The immune response by humans to CoV-2 virus occurs as a combination of the cell-mediated immunity and antibody production, [] just as with most other infections.

In some of these cases, the RNA from the first and second infections indicates a different strain of the virus. The virus is thought to be natural and has an animal origin , [47] through spillover infection.

There are several theories about where the first case the so-called patient zero originated. There were four men and five women reported to be infected in November, but none of them were "patient zero".

By December , the spread of infection was almost entirely driven by human-to-human transmission. That evening, the Wuhan Municipal Health Commission issued a notice to various medical institutions on "the treatment of pneumonia of unknown cause".

The Wuhan Municipal Health Commission made the first public announcement of a pneumonia outbreak of unknown cause on 31 December, confirming 27 cases [] [] [] —enough to trigger an investigation.

During the early stages of the outbreak, the number of cases doubled approximately every seven and a half days. On 31 January , Italy had its first confirmed cases, two tourists from China.

On 11 June , after 55 days without a locally transmitted case, [] Beijing reported the first COVID case, followed by two more cases on 12 June.

Several measures are commonly used to quantify mortality. The death-to-case ratio reflects the number of deaths divided by the number of diagnosed cases within a given time interval.

Based on Johns Hopkins University statistics, the global death-to-case ratio is 2. Other measures include the case fatality rate CFR , which reflects the percentage of diagnosed individuals who die from a disease, and the infection fatality rate IFR , which reflects the percentage of infected individuals diagnosed and undiagnosed who die from a disease.

These statistics are not time-bound and follow a specific population from infection through case resolution.

Many academics have attempted to calculate these numbers for specific populations. Outbreaks have occurred in prisons due to crowding and an inability to enforce adequate social distancing.

The CFR for a disease is the proportion of deaths from the disease compared to the total number of people diagnosed with the disease within a certain period of time.

The IFR, in contrast, is the proportion of deaths among all the infected individuals. Early reviews of epidemiologic data showed greater impact of the pandemic and a higher mortality rate in men in China and Italy.

Greater prevalence of lacking health insurance and care and of underlying conditions such as diabetes , hypertension and heart disease also increase their risk of death.

In the U. During the initial outbreak in Wuhan, China, the virus and disease were commonly referred to as "coronavirus" and "Wuhan coronavirus", [] [] [] with the disease sometimes called "Wuhan pneumonia".

In January , the World Health Organization recommended nCov [] and nCoV acute respiratory disease [] as interim names for the virus and disease per guidance and international guidelines against using geographical locations e.

Wuhan, China , animal species, or groups of people in disease and virus names in part to prevent social stigma. After the initial outbreak of COVID, misinformation and disinformation regarding the origin, scale, prevention, treatment, and other aspects of the disease rapidly spread online.

The pandemic has had many impacts on global health beyond those caused by the COVID disease itself. It has led to a reduction in hospital visits for other reasons.

Humans appear to be capable of spreading the virus to some other animals. A study on domesticated animals inoculated with the virus found that cats and ferrets appear to be "highly susceptible" to the disease, while dogs appear to be less susceptible, with lower levels of viral replication.

The study failed to find evidence of viral replication in pigs , ducks , and chickens. As of August , dozens of domestic cats and dogs had tested positive, though according to the U.

CDC, there was no evidence they transmitted the virus to humans. No medication or vaccine other than remdesivir is approved with the specific indication to treat the disease.

It had previously enrolled 3, patients from 17 countries in the Solidarity Trial. Modelling research has been conducted with several objectives, including predictions of the dynamics of transmission, [] diagnosis and prognosis of infection, [] estimation of the impact of interventions, [] [] or allocation of resources.

Several other types of models have been developed and used during the COVID including computational fluid dynamics models to study the flow physics of COVID, [] retrofits of crowd movement models to study occupant exposure, [] mobility-data based models to investigate transmission, [] or the use of macroeconomic models to assess the economic impact of the pandemic.

There has been a great deal of COVID research, involving accelerated research processes and publishing shortcuts to meet the global demand.

To minimise the harm from misinformation , medical professionals and the public are advised to expect rapid changes to available information, and to be attentive to retractions and other updates.

The COVID Clinical Research Coalition has goals to 1 facilitate rapid reviews of clinical trial proposals by ethics committees and national regulatory agencies, 2 fast-track approvals for the candidate therapeutic compounds, 3 ensure standardised and rapid analysis of emerging efficacy and safety data and 4 facilitate sharing of clinical trial outcomes before publication.

There are mixed results as of 3 April , as to the effectiveness of hydroxychloroquine as a treatment for COVID, with some studies showing little or no improvement.

In June, initial results from a randomised trial in the United Kingdom showed that dexamethasone reduced mortality by one third for patients who are critically ill on ventilators and one fifth for those receiving supplemental oxygen.

There is preliminary evidence that hydroxychloroquine may be useful in controlling cytokine storms in late-phase severe forms of the disease.

Tocilizumab has been included in treatment guidelines by China's National Health Commission after a small study was completed.

Prophylactic tocilizumab has been shown to increase serum IL-6 levels by saturating the IL-6R, driving IL-6 across the blood-brain barrier , and exacerbating neurotoxicity while having no effect on the incidence of CRS.

Transferring purified and concentrated antibodies produced by the immune systems of those who have recovered from COVID to people who need them is being investigated as a non-vaccine method of passive immunisation.

Peru announced in April that it would begin working towards creating a vaccine, with the pharmaceutical company Farvet and Universidad Peruana Cayetano Heredia UPCH announcing plans to jointly develop a vaccine in Chincha.

They also indicated that alpacas have the ability to generate some types of antibodies known as "nanobodies", which are very small and have a greater potential to treat pathogens.

From Wikipedia, the free encyclopedia. Infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2. For an overview of diseases caused by coronaviruses, see Coronavirus disease.

False-color transmission electron microscope image of coronavirus. By continent Africa Antarctica Asia Europe. North America Oceania South America.

Cruise ships Naval ships. Cases Deaths. International response. European Union response Protests U.

Lockdowns Evacuations Travel restrictions International aid. Medical response. Disease testing Vaccine research.

Strikes Xenophobia and racism Notable deaths. Tourism Video games. Main article: Severe acute respiratory syndrome coronavirus 2.

South Korea, as of 17 July []. Spain, as of 18 May []. Italy, as of 3 June []. The number of deaths vs total cases by country and approximate case fatality rate [].

However, no candidate has completed clinical trials to prove its safety and efficacy. Coronavirus disease portal Medicine portal Viruses portal.

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Clinicians trace a ferocious rampage through the body, from brain to toes". John Sperati, updated 14 May Cureus, Inc.

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BMC Medicine. Chinese Medical Journal. Respiratory Medicine. Retrieved 27 March Man, I just fucked up my thumb by slamming it with my hammer!

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